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Article

The impact of mitochondrial and nuclear DNA variants on late-onset Alzheimer's disease risk.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Maruszak Aleksandra, Safranow Krzysztof, Branicki Wojciech, Gawęda-Walerych Katarzyna, Pośpiech Ewelina, Gabryelewicz Tomasz, Canter Jeffrey A, Barcikowska Maria, Zekanowski Cezary

Abstract excerpt

We investigated the potential contribution of mitochondrial DNA (mtDNA) variants, haplogroups, and polymorphisms in nuclear genes essential for mitochondrial biogenesis and function (PGC-1α TFAM) to late-onset Alzheimer's disease (LOAD) risk. Epistatic interaction analysis was conducted between the studied variables. Our results demonstrate that mtDNA haplogroups and subhaplogroups with putative role in partial...

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Identifiers

PMID: 21799244
DOI: 10.3233/JAD-2011-110710

Genes

TFAM
PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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