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Article

Structural diversity and evolutionary constraints of oxidative phosphorylation.

Cell genomics - 10 Sept 2025

Cabrera-Alarcón José Luis, Rosa-Moreno Marina, Sánchez-García Lucía, Hernansanz-Agustín Pablo, Jiménez-Gómez Maria Concepción, Martínez Fernando, Sánchez-Cabo Fátima, Enríquez José Antonio

Abstract excerpt

The oxidative phosphorylation (OxPhos) system is central to metabolism. The more than 90 structural subunits are encoded by different chromosome categories (autosomal, X, and mtDNA). The system is envisioned as an invariant structure between cells and individuals. However, a comprehensive analysis of the 1,000 Genomes Project data reveals unexpected genetic intra-individual variability resulting from the...

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Topics

Oxidative Phosphorylation
Humans
Evolution, Molecular
DNA, Mitochondrial
Genetic Variation
Animals

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Identifiers

PMID: 40614727
DOI: 10.1016/j.xgen.2025.100945
PMCID: PMC12534705

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