Article
Deep sequencing of the mitochondrial genome reveals common heteroplasmic sites in NADH dehydrogenase genes.
Human genetics - 1 Mar 2018
Liu Chunyu, Fetterman Jessica L, Liu Poching, Luo Yan, Larson Martin G, Vasan Ramachandran S, Zhu Jun, Levy Daniel
Abstract excerpt
Increasing evidence implicates mitochondrial dysfunction in aging and age-related conditions. But little is known about the molecular basis for this connection. A possible cause may be mutations in the mitochondrial DNA (mtDNA), which are often heteroplasmic-the joint presence of different alleles at a single locus in the same individual. However, the involvement of mtDNA heteroplasmy in aging and age-related...
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