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Article

Targeted-capture massively-parallel sequencing enables robust detection of clinically informative mutations from formalin-fixed tumours.

Scientific reports - 13 Dec 2013

Wong Stephen Q, Li Jason, Salemi Renato, Sheppard Karen E, Do Hongdo, Tothill Richard W, McArthur Grant A, Dobrovic Alexander

Abstract excerpt

Massively parallel sequencing offers the ability to interrogate a tumour biopsy for multiple mutational changes. For clinical samples, methodologies must enable maximal extraction of available sequence information from formalin-fixed and paraffin-embedded (FFPE) material. We assessed the use of targeted capture for mutation detection in FFPE DNA. The capture probes targeted the coding region of all known kinase...

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Identifiers

PMID: 24336498
DOI: 10.1038/srep03494
PMCID: PMC3861801

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ATM
BRAF
ERBB4
STK11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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