Article
Assessment of Capture and Amplicon-Based Approaches for the Development of a Targeted Next-Generation Sequencing Pipeline to Personalize Lymphoma Management.
The Journal of molecular diagnostics : JMD - 1 Mar 2018
Hung Stacy S, Meissner Barbara, Chavez Elizabeth A, Ben-Neriah Susana, Ennishi Daisuke, Jones Martin R, Shulha Hennady P, Chan Fong Chun, Boyle Merrill, Kridel Robert, Gascoyne Randy D, Mungall Andrew J, Marra Marco A, Scott David W, Connors Joseph M, Steidl Christian
Abstract excerpt
Targeted next-generation sequencing panels are increasingly used to assess the value of gene mutations for clinical diagnostic purposes. For assay development, amplicon-based methods have been preferentially used on the basis of short preparation time and small DNA input amounts. However, capture sequencing has emerged as an alternative approach because of high testing accuracy. We compared capture hybridization...
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