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Article

Assessment of whole genome amplification for sequence capture and massively parallel sequencing.

PloS one - 1 Jan 2014

Hasmats Johanna, Gréen Henrik, Orear Cedric, Validire Pierre, Huss Mikael, Käller Max, Lundeberg Joakim

Abstract excerpt

Exome sequence capture and massively parallel sequencing can be combined to achieve inexpensive and rapid global analyses of the functional sections of the genome. The difficulties of working with relatively small quantities of genetic material, as may be necessary when sharing tumor biopsies between collaborators for instance, can be overcome using whole genome amplification. However, the potential drawbacks of...

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Identifiers

PMID: 24409309
DOI: 10.1371/journal.pone.0084785
PMCID: PMC3883664

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