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Article

Global mutational profiling of formalin-fixed human colon cancers from a pathology archive.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2012

Adams Mark D, Veigl Martina L, Wang Zhenghe, Molyneux Neil, Sun Shuying, Guda Kishore, Yu Xiaoqing, Markowitz Sanford D, Willis Joseph

Abstract excerpt

The advent of Next-Generation sequencing technologies, which significantly increases the throughput and reduces the cost of large-scale sequencing efforts, provides an unprecedented opportunity for discovery of novel gene mutations in human cancers. However, it remains a challenge to apply Next-Generation technologies to DNA extracted from formalin-fixed paraffin-embedded cancer specimens. We describe here the...

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Identifiers

PMID: 22878650
DOI: 10.1038/modpathol.2012.121
PMCID: PMC3697090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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