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Article

Identification of high-confidence somatic mutations in whole genome sequence of formalin-fixed breast cancer specimens.

Nucleic acids research - 1 Aug 2012

Yost Shawn E, Smith Erin N, Schwab Richard B, Bao Lei, Jung HyunChul, Wang Xiaoyun, Voest Emile, Pierce John P, Messer Karen, Parker Barbara A, Harismendy Olivier, Frazer Kelly A

Abstract excerpt

The utilization of archived, formalin-fixed paraffin-embedded (FFPE) tumor samples for massive parallel sequencing has been challenging due to DNA damage and contamination with normal stroma. Here, we perform whole genome sequencing of DNA isolated from two triple-negative breast cancer tumors ar...

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Identifiers

PMID: 22492626
DOI: 10.1093/nar/gks299
PMCID: PMC3413110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22492626-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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