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Article

Mutations adjacent to the end of transmembrane helices 6 and 7 independently affect drug efflux capacity of yeast ABC transporter Pdr5p.

Biochimica et biophysica acta - 1 Mar 2014

Chen Zhigang, Li Jingkai, Wang Wei, Guo Xiaoxian, Li Yongquan, Mao Xuming, Chen Xinyu, Guan Wenjun

Abstract excerpt

As a mammalian p-glycoprotein homolog, Pdr5p is a major ATP-binding cassette transporter for cellular detoxification in the yeast Saccharomyces cerevisiae. In this study, two novel loss-of-function mutations located adjacent to the ends of the predicted transmembrane helices of Pdr5p were identified. C793F and S1230L mutations considerably impaired the transport activity of Pdr5p without affecting the ATPase...

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Identifiers

PMID: 24333836
DOI: 10.1016/j.bbamem.2013.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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