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Article

Loss of function mutation in the yeast multiple drug resistance gene PDR5 causes a reduction in chloramphenicol efflux.

Antimicrobial agents and chemotherapy - 1 Oct 1994

Leonard P J, Rathod P K, Golin J

Abstract excerpt

The yeast (Saccharomyces cerevisiae) PDR5 gene product encodes a 160-kDa protein related to the large ABC family of transporters, including the human MDR1 multidrug resistance p-glycoprotein. Loss of function mutations in PDR5 result in chloramphenicol hypersensitivity. A pdr5::Tn5 loss of function mutant exhibits a markedly impaired efflux of chloramphenicol compared with that of an isogenic PDR5 (wild-type)...

Topics

ATP-Binding Cassette Transporters
Carrier Proteins
Chloramphenicol
Drug Resistance, Multiple
Fungal Proteins
Genes, Fungal
Membrane Proteins
Mutation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 7840595
DOI: 10.1128/AAC.38.10.2492
PMCID: PMC284771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7840595-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Loss of function mutation in the yeast multiple drug resistance gene PDR5 causes a reduction in chloramphenicol efflux.PMID 7840595Read ↗

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