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Article

Second-site suppressor mutations reveal connection between the drug-binding pocket and nucleotide-binding domain 1 of human P-glycoprotein (ABCB1).

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Nov 2023

Murakami Megumi, Sajid Andaleeb, Lusvarghi Sabrina, Durell Stewart R, Abel Biebele, Vahedi Shahrooz, Golin John, Ambudkar Suresh V

Abstract excerpt

Human P-glycoprotein (P-gp) or ABCB1 is overexpressed in many cancers and has been implicated in altering the bioavailability of chemotherapeutic drugs due to their efflux, resulting in the development of chemoresistance. To elucidate the mechanistic aspects and structure-function relationships of P-gp, we previously utilized a tyrosine (Y)-enriched P-gp mutant (15Y) and demonstrated that at least 15 conserved...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37797431
DOI: 10.1016/j.drup.2023.101009
PMCID: PMC10842643

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