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Article

Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p.

The Journal of biological chemistry - 6 Dec 1996

Kolaczkowski M, van der Rest M, Cybularz-Kolaczkowska A, Soumillion J P, Konings W N, Goffeau A

Abstract excerpt

Pdr5p is the yeast Saccharomyces cerevisiae ATP-binding cassette transporter conferring resistance to several unrelated drugs. Its high overproduction in Pdr1p transcription factor mutants allows us to study the molecular mechanism of multidrug transport and substrate specificity. We have developed new in vivo and in vitro assays of Pdr5p-mediated drug transport. We show that in spite of little sequence homology,...

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PMID: 8940170
DOI: 10.1074/jbc.271.49.31543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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