Article
A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2008
Ernst Robert, Kueppers Petra, Klein Cornelia M, Schwarzmueller Tobias, Kuchler Karl, Schmitt Lutz
Abstract excerpt
The yeast ABC transporter Pdr5 plays a major role in drug resistance against a large number of structurally unrelated compounds. Although Pdr5 has been extensively studied, many important aspects regarding its molecular mechanisms remain unresolved. For example, a striking degeneration of conserved amino acid residues exists in the nucleotide binding domains (NBDs), but their functional relevance is unknown....
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