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Article

Mutational analysis of the yeast multidrug resistance ABC transporter Pdr5p with altered drug specificity.

Genes to cells : devoted to molecular & cellular mechanisms - 1 May 2005

Tutulan-Cunita Andreea Cristina, Mikoshi Makoto, Mizunuma Masaki, Hirata Dai, Miyakawa Tokichi

Abstract excerpt

Multidrug resistance ABC transporter Pdr5p of Saccharomyces cerevisiae is particularly important due to its ability to export a wide range of unrelated substrates. To clarify its function, we generated Pdr5p mutants by random mutagenesis and screened for mutants with altered drug specificity in vivo by using 5 drug compounds. Nine point mutations that caused significant changes in drug specificity distributed...

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PMID: 15836770
DOI: 10.1111/j.1365-2443.2005.00847.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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