Article
Mutations in the yeast PDR3, PDR4, PDR7 and PDR9 pleiotropic (multiple) drug resistance loci affect the transcript level of an ATP binding cassette transporter encoding gene, PDR5.
Genetics - 1 Feb 1994
Dexter D, Moye-Rowley W S, Wu A L, Golin J
Abstract excerpt
The yeast pleiotropic (multiple drug) resistance gene PDR5 encodes a product with homology to a large number of membrane transport proteins including the mammalian multiple drug resistance family. In this study, we identified four genes on chromosome II that affect the steady-state level of PDR5...
Topics
- ATP-Binding Cassette Transporters
- Adenosine Triphosphate
- Alleles
- Biological Transport, Active
- Carrier Proteins
- Chromosome Mapping
- Chromosomes, Fungal
- Cycloheximide
- DNA-Binding Proteins
- Drug Resistance, Microbial
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal