Article
Methylation at a transcription factor-binding site on the 5-HT1A receptor gene correlates with negative symptom treatment response in first episode schizophrenia.
The international journal of neuropsychopharmacology - 1 Apr 2014
Tang Hao, Dalton Caroline F, Srisawat Umarat, Zhang Zhi Jun, Reynolds Gavin P
Abstract excerpt
Individual variability and inadequate response of negative symptoms are major limitations of antipsychotic treatment in schizophrenia. A functional polymorphism, rs6295, in the 5-HT1A-receptor gene (HTR1A) contributes to this variability in negative symptom response. The DNA sequence containing r...
Topics
- Adult
- Antipsychotic Agents
- Binding Sites
- China
- DNA Methylation
- Female
- Genotype
- Humans
- Male
- Psychiatric Status Rating Scales
- Receptor, Serotonin, 5-HT1A
- Schizophrenia
- Transcription Factors
- Treatment Outcome
- Young Adult