Article
Risperidone-induced changes in DNA methylation in peripheral blood from first-episode schizophrenia patients parallel changes in neuroimaging and cognitive phenotypes.
Psychiatry research - 1 Nov 2022
Hu Maolin, Xia Yan, Zong Xiaofen, Sweeney John A, Bishop Jeffrey R, Liao Yanhui, Giase Gina, Li Bingshan, Rubin Leah H, Wang Yunpeng, Li Zongchang, He Ying, Chen Xiaogang, Liu Chunyu, Chen Chao, Tang Jinsong
Abstract excerpt
BACKGROUND: Second generation antipsychotics such as risperidone are first-line pharmacotherapy treatment choices for schizophrenia. However, our ability to reliably predict and monitor treatment reaction is impeded by the lack of relevant biomarkers. As a biomarker for the susceptibility of schizophrenia and clozapine treatment response, DNA methylation (DNAm) has been studied, but the impact of antipsychotics...
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