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Article

Functional serotonin 1A receptor variant influences treatment response to atypical antipsychotics in schizophrenia.

Pharmacogenetics and genomics - 1 Jan 2009

Mössner Rainald, Schuhmacher Anna, Kühn Kai-Uwe, Cvetanovska Gabriela, Rujescu Dan, Zill Peter, Quednow Boris B, Rietschel Marcella, Wölwer Wolfgang, Gaebel Wolfgang, Wagner Michael, Maier Wolfgang

Abstract excerpt

The serotonin (5-HT) 1A receptor has been found to be dysregulated in prefrontal cortex and other brain regions in schizophrenia, and 5-HT1A receptor levels in the amygdala have been related to negative schizophrenia symptoms. We have assessed the impact of the functional C-1019G variant of the 5-HT1A receptor on the response to risperidone or haloperidol in a prospective, randomized, double-blind study. Patients...

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Identifiers

PMID: 18849890
DOI: 10.1097/FPC.0b013e328311a917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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