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Article

Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response.

The international journal of neuropsychopharmacology - 1 Aug 2014

Domschke Katharina, Tidow Nicola, Schwarte Kathrin, Deckert Jürgen, Lesch Klaus-Peter, Arolt Volker, Zwanzger Peter, Baune Bernhard T

Abstract excerpt

Variation in the serotonin transporter gene (5-HTT; SERT; SLC6A4) has been suggested to pharmacogenetically drive interindividual differences in antidepressant treatment response. In the present analysis, a 'pharmaco-epigenetic' approach was applied by investigating the influence of DNA methylation patterns in the 5-HTT transcriptional control region on antidepressant treatment response. Ninety-four patients of...

Topics

Antidepressive Agents
Citalopram
DNA Methylation
Depressive Disorder, Major
Drug Resistance
Female
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Retrospective Studies

Serotonin Plasma Membrane Transport Proteins

Treatment Outcome

White People

Source

Identifiers

PMID: 24679990
DOI: 10.1017/S146114571400039X

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24679990-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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