Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional regulation of the 5-HT1A receptor: implications for mental illness.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 5 Sept 2012

Albert Paul R

Abstract excerpt

The serotonin-1A (5-HT(1A)) receptor is an abundant post-synaptic 5-HT receptor (heteroreceptor) implicated in regulation of mood, emotion and stress responses and is the major somatodendritic autoreceptor that negatively regulates 5-HT neuronal activity. Based on animal models, an integrated model for opposing roles of pre- and post-synaptic 5-HT(1A) receptors in anxiety and depression phenotypes and response to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents
Share to Anxiety
Share to Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene-Environment Interaction

Share to Gene Expression Regulation

Share to Receptor, Serotonin, 5-HT1A

Share to Synaptic Transmission

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 22826341
DOI: 10.1098/rstb.2011.0376
PMCID: PMC3405675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional regulation of the 5-HT1A receptor: implications for mental illness.PMID 22826341Read ↗

Transcriptional regulation at a HTR1A polymorphism associated with mental illness.Semantic proximity Read ↗

5-HT1A receptors, gene repression, and depression: guilt by association.Semantic proximity Read ↗

Allelic variation of human serotonin transporter gene expression.Semantic proximity Read ↗

Association of the C(-1019)G 5-HT1A promoter polymorphism with exposure to stressors preceding hospitalization for bipolar depression.Semantic proximity Read ↗

Increased Serotonin-1A (5-HT1A) Autoreceptor Expression and Reduced Raphe Serotonin Levels in Deformed Epidermal Autoregulatory Factor-1 (Deaf-1) Gene Knock-out MiceSemantic proximity Read ↗

Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide.Semantic proximity Read ↗

Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice.Semantic proximity Read ↗

Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapySemantic proximity Read ↗

The serotonin 5-HT7 receptors: two decades of research.Semantic proximity Read ↗

Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex.Semantic proximity Read ↗

Epigenetic Modulation of Mood DisordersSemantic proximity Read ↗

Serotonin receptors in depression: from A to BSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.