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Article

Novel mechanism of action on Hedgehog signaling by a suppressor of fused carboxy terminal variant.

PloS one - 1 Jan 2012

Tostar Ulrica, Finta Csaba, Rahman Mohammed Ferdous-Ur, Shimokawa Takashi, Zaphiropoulos Peter G

Abstract excerpt

The Suppressor of Fused (SUFU) protein plays an essential role in the Hedgehog (HH) signaling pathway, by regulation of the GLI transcription factors. Two major isoforms of human SUFU are known, a full-length (SUFU-FL) and a carboxy-terminal truncated (SUFU- ΔC) variant. Even though SUFU- ΔC is expressed at an equivalent level as SUFU-FL in certain tissues, the function of SUFU-ΔC and its impact on HH signal...

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Source

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Identifiers

PMID: 22666390
DOI: 10.1371/journal.pone.0037761
PMCID: PMC3362617

Genes

SUFU
GLI2
HHIP
PTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Novel mechanism of action on Hedgehog signaling by a suppressor of fused carboxy terminal variant.PMID 22666390Read ↗

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Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.Semantic proximity Read ↗

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