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Article

Mutations in SUFU predispose to medulloblastoma.

Nature genetics - 1 Jul 2002

Taylor Michael D, Liu Ling, Raffel Corey, Hui Chi-chung, Mainprize Todd G, Zhang Xiaoyun, Agatep Ron, Chiappa Sharon, Gao Luzhang, Lowrance Anja, Hao Aihau, Goldstein Alisa M, Stavrou Theodora, Scherer Stephen W, Dura Wieslaw T, Wainwright Brandon, Squire Jeremy A, Rutka James T, Hogg David

Abstract excerpt

The sonic hedgehog (SHH) signaling pathway directs the embryonic development of diverse organisms and is disrupted in a variety of malignancies. Pathway activation is triggered by binding of hedgehog proteins to the multipass Patched-1 (PTCH) receptor, which in the absence of hedgehog suppresses the activity of the seven-pass membrane protein Smoothened (SMOH). De-repression of SMOH culminates in the activation...

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Share to Cerebellar Neoplasms
Share to Chromosomes, Human, Pair 10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Consensus Sequence

Share to Genes, Suppressor

Share to Germ-Line Mutation

Share to Holoprosencephaly

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Source

Identifiers

PMID: 12068298
DOI: 10.1038/ng916

Genes

SHH
SUFU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in SUFU predispose to medulloblastoma.PMID 12068298Read ↗

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