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Article

Polymorphisms in the CD1d promoter that regulate CD1d gene expression are associated with impaired NKT cell development.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2014

Borg Zachary D, Benoit Patrick J, Lilley Graham W J, Aktan Idil, Chant Alan, DeVault Victoria L, Rincon Mercedes, Boyson Jonathan E

Abstract excerpt

CD1d-restricted NKT cells comprise an innate-like T cell population that exerts significant influence over early events in the developing immune response. The frequency of NKT cells is highly variable in humans and in mice, but the basis for this variability remains unclear. In this study, we report a striking deficiency of type I NKT cells in the wild-derived inbred strains PWD/PhJ, SPRET/EiJ, and CAST/EiJ....

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Share to Antigen Presentation
Share to Antigens, CD1d

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Natural Killer T-Cells

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Share to Thymocytes

Source

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Identifiers

PMID: 24307737
DOI: 10.4049/jimmunol.1301451
PMCID: PMC3903119

Genes

CAST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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