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Article

Inbred Strain Characteristics Impact the NKT Cell Repertoire.

ImmunoHorizons - 31 Mar 2021

Shissler Susannah C, Bates Joshua P, Hester Danubia, Jones Laundette P, Webb Tonya J

Abstract excerpt

NKT cells are primed lymphocytes that rapidly secrete cytokines and can directly kill cancerous cells. Given the critical role NKT cells play in cancer immune surveillance, we sought to investigate the effect of mutations in Brca1, specifically a conditional deletion of exon 11, on type I invariant NKT cell development. We observed a significant reduction in invariant NKT cells in both primary lymphoid and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33789929
DOI: 10.4049/immunohorizons.2000066
PMCID: PMC12934451

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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