Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model.

Arthritis and rheumatism - 1 Apr 2007

Yang Jun-Qi, Wen Xiangshu, Liu Hongzhu, Folayan Gbolahan, Dong Xin, Zhou Min, Van Kaer Luc, Singh Ram Raj

Abstract excerpt

OBJECTIVE: CD1d-reactive invariant natural killer T (iNKT) cells secrete multiple cytokines upon T cell receptor (TCR) engagement and modulate many immune-mediated conditions. The purpose of this study was to examine the role of these cells in the development of autoimmune disease in genetically lupus-prone (NZBxNZW)F1 (BWF1) mice. METHODS: The CD1d1-null genotype was crossed onto the NZB and NZW backgrounds to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD1
Share to Antigens, CD1d

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Killer Cells, Natural

Share to Lupus Erythematosus, Systemic

Share to Lupus Nephritis

Share to Mice, Inbred NZB

Share to Spleen

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 17393451
DOI: 10.1002/art.22490
PMCID: PMC2291538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model.PMID 17393451Read ↗

Functional dissection of lupus susceptibility loci on the New Zealand black mouse chromosome 1: evidence for independent genetic loci affecting T and B cell activation.Semantic proximity Read ↗

Cutting Edge: A Role for CD1 in the Pathogenesis of Lupus in NZB/NZW MiceSemantic proximity Read ↗

Aberrant genetic control of invariant TCR-bearing NKT cell function in New Zealand mouse strains: possible involvement in systemic lupus erythematosus pathogenesis.Semantic proximity Read ↗

The lupus phenotype in B6.NZBc1 congenic mice reflects interactions between multiple susceptibility loci and a suppressor locus.Semantic proximity Read ↗

Type I interferon signaling is involved in the spontaneous development of lupus-like disease in B6.Nba2 and (B6.Nba2 x NZW)F(1) mice.Semantic proximity Read ↗

Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus.Semantic proximity Read ↗

CD4+ T lymphocytes with constitutive CD40 ligand in preautoimmune (NZB x NZW)F1 lupus-prone mice: phenotype and possible role in autoreactivity.Semantic proximity Read ↗

NK1.1- natural killer T cells upregulate interleukin-17 expression in experimental lupus nephritis.Semantic proximity Read ↗

S100a9 Protects Male Lupus-Prone NZBWF1 Mice From Disease Development.Semantic proximity Read ↗

Impact of Fli-1 transcription factor on autoantibody and lupus nephritis in NZM2410 miceSemantic proximity Read ↗

Breaking Tolerance to Double Stranded DNA, Nucleosome, and Other Nuclear Antigens Is Not Required for the Pathogenesis of Lupus GlomerulonephritisSemantic proximity Read ↗

NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.