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Article

Genetic control of murine invariant natural killer T cells maps to multiple type 1 diabetes regions.

Genes and immunity - 1 Sept 2013

Tsaih S W, Khaja S, Ciecko A E, MacKinney E, Chen Y G

Abstract excerpt

Reduced frequency of invariant natural killer T (iNKT) cells has been indicated as a contributing factor to type 1 diabetes (T1D) development in NOD mice. To further understand the genetic basis of the defect, we generated (NOD × ICR)F2 mice to map genes that control iNKT-cell development. We determined frequencies of thymic and splenic iNKT cells, as well as the ratio of CD4-positive and -negative subsets in the...

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Share to Chromosomes, Mammalian
Share to Diabetes Mellitus, Type 1
Share to Mice, Inbred ICR

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred NOD

Share to Natural Killer T-Cells

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Source

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Identifiers

PMID: 23719031
DOI: 10.1038/gene.2013.32
PMCID: PMC3766462

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