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Genetic influence on splenic natural killer cell frequencies and maturation among aged mice.

Experimental gerontology - 1 Apr 2018

Bumgardner S A, Zhou Y, Jiang Z, Coe E J, Yakaitis C L, Xiao Y, Pazdro R

Abstract excerpt

Natural killer (NK) cells are cytotoxic innate lymphocytes that are integral to host defenses against viruses and neoplastic cells. Aging causes phenotypic and functional impairment of NK cells, which diminishes innate immune surveillance, yet the factors that determine the aged NK cell phenotype have not been completely defined. For instance, the genetic basis of the aged NK cell phenotype has not been...

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PMID: 29355703
DOI: 10.1016/j.exger.2018.01.010

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