Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic resistance to scrapie infection in experimentally challenged goats.

Journal of virology - 1 Mar 2014

Lacroux Caroline, Perrin-Chauvineau Cécile, Corbière Fabien, Aron Naima, Aguilar-Calvo Patricia, Torres Juan Maria, Costes Pierrette, Brémaud Isabelle, Lugan Séverine, Schelcher François, Barillet Francis, Andréoletti Olivier

Abstract excerpt

In goats, several field studies have identified coding mutations of the gene encoding the prion protein (I/M142, N/D146, S/D146, R/Q211, and Q/K222) that are associated with a lower risk of developing classical scrapie. However, the data related to the levels of resistance to transmissible spongiform encephalopathies (TSEs) of these different PRNP gene mutations are still considered insufficient for developing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Codon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Goat Diseases

Share to PrPSc Proteins

Share to Scrapie

Share to Tissue Distribution

Source

Open in PubMed Open full text

Identifiers

PMID: 24284317
DOI: 10.1128/JVI.02872-13
PMCID: PMC3958109

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic resistance to scrapie infection in experimentally challenged goats.PMID 24284317Read ↗

Goats singly heterozygous for PRNP S146 or K222 orally inoculated with classical scrapie at birth show no disease at ages well beyond 6 years.Semantic proximity Read ↗

Resistance to classical scrapie in experimentally challenged goats carrying mutation K222 of the prion protein gene.Semantic proximity Read ↗

Genetic and Pathological Follow-Up Study of Goats Experimentally and Naturally Exposed to a Sheep Scrapie Isolate.Semantic proximity Read ↗

Prion gene (PRNP) haplotype variation in United States goat breeds (Open Access publication).Semantic proximity Read ↗

Effect of Polymorphisms at Codon 146 of the Goat PRNP Gene on Susceptibility to Challenge with Classical Scrapie by Different Routes.Semantic proximity Read ↗

PrP-associated resistance to scrapie in five highly infected goat herds.Semantic proximity Read ↗

Effect of Q211 and K222 PRNP Polymorphic Variants in the Susceptibility of Goats to Oral Infection With Goat Bovine Spongiform Encephalopathy.Semantic proximity Read ↗

Identification of an allelic variant of the goat PrP gene associated with resistance to scrapie.Semantic proximity Read ↗

Incomplete protection of the K222 polymorphism of the prion protein gene after intracerebral exposure to caprine BSE in goats: preliminary follow-up in S127 carriers.Semantic proximity Read ↗

Prion protein gene polymorphisms in Turkish native goat breeds.Semantic proximity Read ↗

Role of the goat K222-PrP(C) polymorphic variant in prion infection resistance.Semantic proximity Read ↗

Comparative Susceptibility of Sheep of Different Origins, Breeds and PRNP Genotypes to Challenge with Bovine Spongiform Encephalopathy and Scrapie.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.