Comparative Susceptibility of Sheep of Different Origins, Breeds and PRNP Genotypes to Challenge with Bovine Spongiform Encephalopathy and Scrapie.

doi:10.1371/journal.pone.0143251

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Article

Comparative Susceptibility of Sheep of Different Origins, Breeds and PRNP Genotypes to Challenge with Bovine Spongiform Encephalopathy and Scrapie.

PloS one - 1 Jan 2015

Houston Fiona, Goldmann Wilfred, Foster James, González Lorenzo, Jeffrey Martin, Hunter Nora

Abstract excerpt

Sheep are natural hosts of the prion disease, scrapie. They are also susceptible to experimental challenge with various scrapie strains and with bovine spongiform encephalopathy (BSE), which affects cattle and has been accidentally transmitted to a range of other species, including man. Incidence and incubation period of clinical disease in sheep following inoculation is controlled by the PRNP gene, which has...

Topics

Alleles
Animals
Brain
Cattle
Codon
Encephalopathy, Bovine Spongiform
Genetic Predisposition to Disease
Genotype
Homozygote
Lymph Nodes
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prions

Scrapie

Sheep

Sheep Diseases

Sheep, Domestic

Species Specificity

Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 26587837
DOI: 10.1371/journal.pone.0143251
PMCID: PMC4654545

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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