Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Goats singly heterozygous for PRNP S146 or K222 orally inoculated with classical scrapie at birth show no disease at ages well beyond 6 years.

Veterinary journal (London, England : 1997) - 1 Mar 2018

Cinar M U, Schneider D A, Waldron D F, O'Rourke K I, White S N

Abstract excerpt

Scrapie is a transmissible spongiform encephalopathy of sheep and goats, and scrapie eradication programs in many parts of the world rely on strong genetic resistance to classical scrapie in sheep. However, the utility of putative resistance alleles in goats has been a focus of research because goats can transmit scrapie to sheep and may serve as a scrapie reservoir. Prior work showed that disease-free survival...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Reservoirs
Share to Disease Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterozygote

Share to Prion Diseases

Share to Prion Proteins

Share to Scrapie

Source

Identifiers

PMID: 29486874
DOI: 10.1016/j.tvjl.2017.12.019

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Goats singly heterozygous for PRNP S146 or K222 orally inoculated with classical scrapie at birth show no disease at ages well beyond 6 years.PMID 29486874Read ↗

Genetic resistance to scrapie infection in experimentally challenged goats.Semantic proximity Read ↗

Genetic and Pathological Follow-Up Study of Goats Experimentally and Naturally Exposed to a Sheep Scrapie Isolate.Semantic proximity Read ↗

Prion gene (PRNP) haplotype variation in United States goat breeds (Open Access publication).Semantic proximity Read ↗

Large-scale survey of prion protein genetic variability in scrapie disease-free goats from the United States.Semantic proximity Read ↗

Incomplete protection of the K222 polymorphism of the prion protein gene after intracerebral exposure to caprine BSE in goats: preliminary follow-up in S127 carriers.Semantic proximity Read ↗

Variation in the prion protein sequence in Dutch goat breeds.Semantic proximity Read ↗

Resistance to classical scrapie in experimentally challenged goats carrying mutation K222 of the prion protein gene.Semantic proximity Read ↗

Novel Variations in Native Ethiopian Goat breeds PRNP Gene and Their Potential Effect on Prion Protein Stability.Semantic proximity Read ↗

Prion protein genotype survey confirms low frequency of scrapie-resistant K222 allele in British goat herds.Semantic proximity Read ↗

The shortest known prion protein gene allele occurs in goats, has only three octapeptide repeats and is non-pathogenic.Semantic proximity Read ↗

Biology of PrPsc accumulation in two natural scrapie-infected sheep flocks.Semantic proximity Read ↗

Perspectives of a scrapie resistance breeding scheme targeting Q211, S146 and K222 caprine PRNP alleles in Greek goats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.