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Article

Effect of Q211 and K222 PRNP Polymorphic Variants in the Susceptibility of Goats to Oral Infection With Goat Bovine Spongiform Encephalopathy.

The Journal of infectious diseases - 15 Aug 2015

Aguilar-Calvo Patricia, Fast Christine, Tauscher Kerstin, Espinosa Juan-Carlos, Groschup Martin H, Nadeem Muhammad, Goldmann Wilfred, Langeveld Jan, Bossers Alex, Andreoletti Olivier, Torres Juan-María

Abstract excerpt

BACKGROUND: The prion protein-encoding gene (PRNP) is one of the major determinants for scrapie occurrence in sheep and goats. However, its effect on bovine spongiform encephalopathy (BSE) transmission to goats is not clear. METHODS: Goats harboring wild-type, R/Q211 or Q/K222 PRNP genotypes were orally inoculated with a goat-BSE isolate to assess their relative susceptibility to BSE infection. Goats were killed...

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Identifiers

PMID: 25722297
DOI: 10.1093/infdis/jiv112

Genes

PRNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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