Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of Polymorphisms at Codon 146 of the Goat PRNP Gene on Susceptibility to Challenge with Classical Scrapie by Different Routes.

Journal of virology - 15 Nov 2017

Papasavva-Stylianou Penelope, Simmons Marion Mathieson, Ortiz-Pelaez Angel, Windl Otto, Spiropoulos John, Georgiadou Soteria

Abstract excerpt

This report presents the results of experimental challenges of goats with scrapie by both the intracerebral (i.c.) and oral routes, exploring the effects of polymorphisms at codon 146 of the goat PRNP gene on resistance to disease. The results of these studies illustrate that while goats of all genotypes can be infected by i.c. challenge, the survival distribution of the animals homozygous for asparagine at codon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Codon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PRNP gene

Share to Genetic Predisposition to Disease

Share to Polymorphism, Genetic

Share to Prion Proteins

Share to Scrapie

Source

Open in PubMed Open full text

Identifiers

PMID: 28878088
DOI: 10.1128/JVI.01142-17
PMCID: PMC5660499

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of Polymorphisms at Codon 146 of the Goat PRNP Gene on Susceptibility to Challenge with Classical Scrapie by Different Routes.PMID 28878088Read ↗

PrP gene polymorphisms in Cyprus goats and their association with resistance or susceptibility to natural scrapie.Semantic proximity Read ↗

Prion protein gene polymorphisms in Turkish native goat breeds.Semantic proximity Read ↗

Genetic resistance to scrapie infection in experimentally challenged goats.Semantic proximity Read ↗

Novel polymorphisms at codons 146 and 151 in the prion protein gene of Cyprus goats, and their association with natural scrapie.Semantic proximity Read ↗

Different allelic effects of the codons 136 and 171 of the prion protein gene in sheep with natural scrapie.Semantic proximity Read ↗

Five novel PRNP gene polymorphisms and their potential effect on Scrapie susceptibility in three native Ethiopian sheep breeds.Semantic proximity Read ↗

Influence of polymorphisms in the prion protein gene on the pathogenesis and neuropathological phenotype of sheep scrapie after oral infection.Semantic proximity Read ↗

Exploring the genetic variability of the PRNP gene at codons 127, 142, 146, 154, 211, 222, and 240 in goats farmed in the Lombardy Region, Italy.Semantic proximity Read ↗

Influence of the prion protein gene, Prnp, on scrapie susceptibility in sheep.Semantic proximity Read ↗

Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrPC.Semantic proximity Read ↗

Identification of seven haplotypes of the caprine PrP gene at codons 127, 142, 154, 211, 222 and 240 in French Alpine and Saanen breeds and their association with classical scrapie.Semantic proximity Read ↗

Goats singly heterozygous for PRNP S146 or K222 orally inoculated with classical scrapie at birth show no disease at ages well beyond 6 years.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.