Article
Identification of an allelic variant of the goat PrP gene associated with resistance to scrapie.
The Journal of general virology - 1 May 2006
Vaccari Gabriele, Bari Michele A Di, Morelli Luisella, Nonno Romolo, Chiappini Barbara, Antonucci Giovanni, Marcon Stefano, Esposito Elena, Fazzi Paola, Palazzini Nadia, Troiano Pasquale, Petrella Antonio, Di Guardo Giovanni, Agrimi Umberto
Abstract excerpt
The association between PrP gene variations and scrapie susceptibility was studied in a single herd of Ionica breed goats. The entire herd comprised 100 animals, 11 of which were clinically affected and showed pathological prion protein (PrP(Sc)) deposition in both their central nervous system (CNS) and lymphoreticular system (LRS). Among asymptomatic goats, nine harboured PrP(Sc) in both CNS and LRS, 19 showed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.