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Article

Modulation of human α-synuclein aggregation by a combined effect of calcium and dopamine.

Neurobiology of disease - 1 Mar 2014

Jain Manish Kumar, Bhat Rajiv

Abstract excerpt

Parkinson's disease is characterized by the deposition of aggregated α-syn and its familial mutants into Lewy bodies leading to death of dopaminergic neurons. α-syn is involved in Ca(II) and dopamine (DA) signaling and their adequate balance inside neuronal cytoplasm is essential for maintaining healthy dopaminergic neurons. We have probed the binding energetics of Ca(II) and DA to human α-syn and its familial...

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PMID: 24269918
DOI: 10.1016/j.nbd.2013.11.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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