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Article

Different species of alpha-synuclein oligomers induce calcium influx and seeding.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Aug 2007

Danzer Karin M, Haasen Dorothea, Karow Anne R, Moussaud Simon, Habeck Matthias, Giese Armin, Kretzschmar Hans, Hengerer Bastian, Kostka Marcus

Abstract excerpt

Aggregation of alpha-synuclein (alpha-syn) has been linked to the pathogenesis of Parkinson's disease (PD) and other neurodegenerative diseases. Increasing evidence suggests that prefibrillar oligomers and protofibrils, rather than mature fibrils of alpha-syn, are the pathogenic species in PD. Despite extensive effort on studying oligomerization of alpha-syn, no studies have compared different oligomer species...

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Identifiers

PMID: 17715357
DOI: 10.1523/JNEUROSCI.2617-07.2007
PMCID: PMC6672196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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