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Article

Mechanism of flavonoid myricetin modulated aggregation in α-Synuclein and its familial mutants E46K and A30P.

Archives of biochemistry and biophysics - 1 Aug 2025

Tinku, Prajapati Anitadevi K, Sahoo Satrujeet, Deepak G, Nair Soumya, Choudhary Sinjan

Abstract excerpt

Inhibiting the aggregation of α-Synuclein (α-Syn) and its familial mutants E46K and A30P has emerged as one of the effective therapeutic strategies against Parkinson's disease (PD). The inhibition and modulation of α-Syn/E46K/A30P fibrillation as well as disaggregation of their pre-formed fibrils by a natural flavonoid myricetin (Myr) is studied. The binding of Myr with α-Syn and its mutants with the affinity...

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PMID: 40383467
DOI: 10.1016/j.abb.2025.110470

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