Article
Comparison of Kinetics, Toxicity, Oligomer Formation, and Membrane Binding Capacity of α-Synuclein Familial Mutations at the A53 Site, Including the Newly Discovered A53V Mutation.
Biochemistry - 4 Sept 2018
Mohite Ganesh M, Kumar Rakesh, Panigrahi Rajlaxmi, Navalkar Ambuja, Singh Nitu, Datta Debalina, Mehra Surabhi, Ray Soumik, Gadhe Laxmikant G, Das Subhadeep, Singh Namrata, Chatterjee Debdeep, Kumar Ashutosh, Maji Samir K
Abstract excerpt
The involvement of α-synuclein (α-Syn) amyloid formation in Parkinson's disease (PD) pathogenesis is supported by the discovery of α-Syn gene (SNCA) mutations linked with familial PD, which are known to modulate the oligomerization and aggregation of α-Syn. Recently, the A53V mutation has been discovered, which leads to late-onset PD. In this study, we characterized for the first time the biophysical properties...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.