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Article

Adenine bolsters the monomeric conformations of the intrinsically disordered A53T mutant of α-Synuclein protein.

Computational biology and chemistry - 1 Feb 2026

Singh Payal, Akhtar Almas, Admane Nikita, Grover Abhinav

Abstract excerpt

Parkinson's disease (PD) is significantly characterized by the accumulation of α-synuclein (α-Syn) amyloid aggregates, especially in the form of Lewy bodies. Our study explores the effect of one of the four nucleobases, adenine, on the amyloid transformation of the A53T mutant of α-Syn (A53T Syn), which is linked to the early-onset PD characterized by increased protofibril production and fast aggregation....

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PMID: 40882443
DOI: 10.1016/j.compbiolchem.2025.108661

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AFM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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