Article

Live-cell micromanipulation of a genomic locus reveals interphase chromatin mechanics

2021-04-21

Abstract excerpt

Our understanding of the physical principles organizing the genome in the nucleus is limited by the lack of tools to directly exert and measure forces on interphase chromosomes in vivo and probe their material nature. Here, we present a novel approach to actively manipulate a genomic locus using controlled magnetic forces inside the nucleus of a living human cell. We observe viscoelastic displacements over micron...

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Identifiers and source

Literature Corpus work: d44e3285-0b17-5628-be27-852d2b69d064
DOI: 10.1101/2021.04.20.439763

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