Article
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry.
Nature immunology - 1 Jan 2010
Travassos Leonardo H, Carneiro Leticia A M, Ramjeet Mahendrasingh, Hussey Seamus, Kim Yun-Gi, Magalhães João G, Yuan Linda, Soares Fraser, Chea Evelyn, Le Bourhis Lionel, Boneca Ivo G, Allaoui Abdelmounaaim, Jones Nicola L, Nuñez Gabriel, Girardin Stephen E, Philpott Dana J
Abstract excerpt
Autophagy is emerging as a crucial defense mechanism against bacteria, but the host intracellular sensors responsible for inducing autophagy in response to bacterial infection remain unknown. Here we demonstrated that the intracellular sensors Nod1 and Nod2 are critical for the autophagic response to invasive bacteria. By a mechanism independent of the adaptor RIP2 and transcription factor NF-kappaB, Nod1 and...
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