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Article

Crohn's disease: NOD2, autophagy and ER stress converge.

Gut - 1 Nov 2011

Fritz Teresa, Niederreiter Lukas, Adolph Timon, Blumberg Richard S, Kaser Arthur

Abstract excerpt

Polymorphisms in NOD2, encoding an intracellular pattern recognition receptor, contribute the largest fraction of genetic risk for Crohn's disease among the >40 risk loci identified so far. Autophagy plays a prominent role in the innate immune response towards intracellular bacteria. The discovery of the autophagy genes ATG16L1 and IRGM as risk factors for Crohn's disease turned autophagy into the spotlight in...

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Source

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Identifiers

PMID: 21252204
DOI: 10.1136/gut.2009.206466
PMCID: PMC3897479

Genes

NOD2
IRGM
ORMDL3
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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