Article
Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2.
Gut - 1 Sept 2011
Plantinga Theo S, Crisan Tania O, Oosting Marije, van de Veerdonk Frank L, de Jong Dirk J, Philpott Dana J, van der Meer Jos W M, Girardin Stephen E, Joosten Leo A B, Netea Mihai G
Abstract excerpt
OBJECTIVE: Autophagy has recently been shown to modulate the production of pro-inflammatory cytokine production and to contribute to antigen processing and presentation through the major histocompatibility complex. Genetic variation in the autophagy gene ATG16L1 has been recently implicated in Crohn's disease pathogenesis. The mechanisms underlying this association are not yet known, although experimental models...
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