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Article

The complex interplay of NOD-like receptors and the autophagy machinery in the pathophysiology of Crohn disease.

European journal of cell biology - 1 Jan 2000

Billmann-Born Susanne, Lipinski Simone, Böck Janne, Till Andreas, Rosenstiel Philip, Schreiber Stefan

Abstract excerpt

Several coding variants of NOD2 and ATG16L1 are associated with increased risk of Crohn disease (CD). NOD2, a cytosolic receptor of the innate immune system activates pro-inflammatory signalling cascades upon recognition of bacterial muramyl dipeptide, but seems also to be involved in antiviral and anti-parasitic defence programs. The CD associated variant L1007fsinsC leads to impaired pro-inflammatory signalling...

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Source

Identifiers

PMID: 21146253
DOI: 10.1016/j.ejcb.2010.10.015

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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