Article
Alterations of autophagic and innate immune responses by the Crohn's disease-associated ATG16L1 mutation.
World journal of gastroenterology - 14 Jul 2022
Okai Natsuki, Watanabe Tomohiro, Minaga Kosuke, Kamata Ken, Honjo Hajime, Kudo Masatoshi
Abstract excerpt
Crohn's disease (CD) is driven by the loss of tolerance to intestinal microbiota and excessive production of pro-inflammatory cytokines. These pro-inflammatory cytokines are produced by macrophages and dendritic cells (DCs) upon sensing the intestinal microbiota by the pattern recognition receptors (PRRs). Impaired activation of PRR-mediated signaling pathways is associated with chronic gastrointestinal...
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