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Article

ATG16L1 polymorphisms are associated with NOD2-induced hyperinflammation.

Autophagy - 1 Sept 2011

Plantinga Theo S, Joosten Leo A B, Netea Mihai G

Abstract excerpt

In recent years considerable advances in understanding the pathogenesis of Crohn disease have been achieved, with the identification of susceptibility variants of genes that are part of the autophagy machinery, i.e., ATG16L1 and IRGM. Subsequent functional studies have been conducted to unravel the underlying mechanism of this genetic association. For the ATG16L1 Thr300Ala polymorphism (c.898A > G, rs2241880), it...

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Source

Identifiers

PMID: 21673517
DOI: 10.4161/auto.7.9.15867

Genes

NOD2
IRGM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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