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Article

Myeloid ATG16L1 Facilitates Host-Bacteria Interactions in Maintaining Intestinal Homeostasis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2017

Zhang Hong, Zheng Libo, McGovern Dermot P B, Hamill Ariel M, Ichikawa Ryan, Kanazawa Yoshitake, Luu Justin, Kumagai Kotaro, Cilluffo Marianne, Fukata Masayuki, Targan Stephan R, Underhill David M, Zhang Xiaolan, Shih David Q

Abstract excerpt

Intact ATG16L1 plays an essential role in Paneth cell function and intestinal homeostasis. However, the functional consequences of ATG16L1 deficiency in myeloid cells, particularly macrophages, are not fully characterized. We generated mice with Atg16l1 deficiency in myeloid and dendritic cells and showed that mice with myeloid Atg16l1 deficiency had exacerbated colitis in two acute and one chronic model of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28130498
DOI: 10.4049/jimmunol.1601293
PMCID: PMC5322190

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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