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Article

Akt2/LDLr double knockout mice display impaired glucose tolerance and develop more complex atherosclerotic plaques than LDLr knockout mice.

Cardiovascular research - 1 Feb 2014

Rensing Katrijn L, de Jager Saskia C A, Stroes Erik S, Vos Mariska, Twickler Marcel Th B, Dallinga-Thie Geesje M, de Vries Carlie J M, Kuiper Johan, Bot Ilze, von der Thüsen Jan H

Abstract excerpt

AIM: To characterize the phenotype of Akt2/low-density-lipoprotein receptor double knockout (dKO) (Akt2/LDLr dKO) mice with respect to insulin resistance and features of atherosclerotic plaque progression. METHODS AND RESULTS: Metabolic profile and atherosclerotic plaque progression were compared between LDLr KO mice and Akt2/LDLr dKO mice. Total cholesterol, glucose, and insulin levels were significantly higher...

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PMID: 24220638
DOI: 10.1093/cvr/cvt252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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