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Article

In vivo inhibition of nuclear factor of activated T-cells leads to atherosclerotic plaque regression in IGF-II/LDLR-/-ApoB100/100 mice.

Diabetes & vascular disease research - 1 Jul 2018

Blanco Fabiana, Heinonen Suvi E, Gurzeler Erika, Berglund Lisa M, Dutius Andersson Anna-Maria, Kotova Olga, Jönsson-Rylander Ann-Cathrine, Ylä-Herttuala Seppo, Gomez Maria F

Abstract excerpt

AIMS: Despite vast clinical experience linking diabetes and atherosclerosis, the molecular mechanisms leading to accelerated vascular damage are still unclear. Here, we investigated the effects of nuclear factor of activated T-cells inhibition on plaque burden in a novel mouse model of type 2 diabetes that better replicates human disease. METHODS & RESULTS: IGF-II/LDLR-/-ApoB100/100 mice were generated by...

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Identifiers

PMID: 29499628
DOI: 10.1177/1479164118759220
PMCID: PMC6039864

Genes

LDLR
NOX4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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