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Article

Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis.

Clinical science (London, England : 1979) - 1 Oct 2017

Thompson Dawn, Morrice Nicola, Grant Louise, Le Sommer Samantha, Lees Emma K, Mody Nimesh, Wilson Heather M, Delibegovic Mirela

Abstract excerpt

Cardiovascular disease (CVD) is the most prevalent cause of mortality among patients with type 1 or type 2 diabetes, due to accelerated atherosclerosis. Recent evidence suggests a strong link between atherosclerosis and insulin resistance, due to impaired insulin receptor (IR) signalling. Here, we demonstrate that inhibiting the activity of protein tyrosine phosphatase 1B (PTP1B), the major negative regulator of...

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Open in PubMed Open full text

Identifiers

PMID: 28899902
DOI: 10.1042/CS20171066
PMCID: PMC6365594

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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