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Article

TRAF3IP2 mediates atherosclerotic plaque development and vulnerability in ApoE(-/-) mice.

Atherosclerosis - 1 Sept 2016

Sakamuri Siva Sankara Vara Prasad, Higashi Yusuke, Sukhanov Sergiy, Siddesha Jalahalli M, Delafontaine Patrice, Siebenlist Ulrich, Chandrasekar Bysani

Abstract excerpt

BACKGROUND AND AIMS: Atherosclerosis is a major cause of heart attack and stroke. Inflammation plays a critical role in the development of atherosclerosis. Since the cytoplasmic adaptor molecule TRAF3IP2 (TRAF3-Interacting Protein 2) plays a causal role in various autoimmune and inflammatory diseases, we hypothesized that TRAF3IP2 mediates atherosclerotic plaque development. METHODS: TRAF3IP2/ApoE double knockout...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27237075
DOI: 10.1016/j.atherosclerosis.2016.05.029
PMCID: PMC5035578

Genes

ADAM17
CXCL1
ICAM1
RECK
TIMP1
TRAF3
VCAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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